2,4-Dichloro-5-fluoropyrimidine → HCID 22060381, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[F:10][C:11]([F:39])([F:38])[C:12]1[CH:13]=[C:14]([CH:22]([NH2:37])[C:23]2[CH:28]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:26]=[C:25]([C:33]([F:36])([F:35])[F:34])[CH:24]=2)[CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=1>>[Cl:1][C:2]1[N:7]=[C:6]([NH:37][CH:22]([C:14]2[CH:15]=[C:16]([C:18]([F:19])([F:20])[F:21])[CH:17]=[C:12]([C:11]([F:10])([F:38])[F:39])[CH:13]=2)[C:23]2[CH:24]=[C:25]([C:33]([F:36])([F:35])[F:34])[CH:26]=[C:27]([C:29]([F:30])([F:31])[F:32])[CH:28]=2)[C:5]([F:9])=[CH:4][N:3]=1Komponenten
3
Versuchsvorschrift
In like manner to the preparation of 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine, 2,4-dichloro-5-fluoropyrimidine was reacted with di[3,5-di(trifluoromethyl)phenyl]methylamine to provide 2-chloro-N4-[[di(3,5-di(trifluoromethyl)phenyl)]methyl]-5-fluoro-4-pyrimidineamine. 1H NMR (CDCl3): δ 8.06 (d, 1H, J=2.3 Hz), 7.92 (s, 2H), 7.74 (s, 4H), 6.75 (d, 1H, J=7.6 Hz), 5.80 (d, 1H, J=7.0 Hz).
Quellen und Nachweise
- ORD-Eintrag
- ord-7534b9c12fa9443ea869948766fb7690
- Quelldatensatz
- uspto-grants-2011_03
- DOI