{[2-(Tert-butoxycarbonylamino)-ethyl]-methyl-amino}-acetic acid benzyl ester → HCID 22270159, Verbindung

HRID 604329

Reaktionsgleichung

Reaktionsgleichung von HRID 604329
C([O:8][C:9](=[O:23])[CH2:10][N:11]([CH2:13][CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH3:12])C1C=CC=CC=1>CO.[C].[Pd]>[C:19]([O:18][C:16]([NH:15][CH2:14][CH2:13][N:11]([CH2:10][C:9]([OH:23])=[O:8])[CH3:12])=[O:17])([CH3:22])([CH3:20])[CH3:21]

Komponenten

4

Edukt 1

HCID 59650730{[2-(Tert-butoxycarbonylamino)-ethyl]-methyl-amino}-acetic acid benzyl ester

Produkt 1

HCID 22270159HCID 22270159, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

162 mg (0.5 mmol) of {[2-(tert-butoxycarbonylamino)-ethyl]-methyl-amino}-acetic acid benzyl ester prepared in Process 3-A was dissolved in methanol (5 mL), and then 5% palladium-carbon was added to it, and this was stirred under a hydrogen atmosphere at room temperature for one hour. After filtering off the insoluble material, the filtrate was concentrated to yield 116 mg (100%) of {[2-(tert-butoxycarbonylamino)-ethyl]-methyl-amino}-acetic acid as a colorless viscous oil.

Aufarbeitung

  1. filtrationAfter filtering off the insoluble material
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-ff223f195c56441a9335cabe75f560e4
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07910593B2

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