Triethylamine → HCID 57709615, Verbindung

HRID 604492Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 604492
[NH2:1][C:2]1[S:3][C:4]([C:13]([NH:15][NH2:16])=[O:14])=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.C(N(CC)CC)C.[C:24](N1C=CN=C1)(N1C=CN=C1)=[O:25]>O1CCCC1>[NH2:1][C:2]1[S:3][C:4]([C:13]2[O:14][C:24](=[O:25])[NH:16][N:15]=2)=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 14819492-amino-4-phenyl-1,3-thiazole-5-carbohydrazide

Produkt 1

HCID 57709615HCID 57709615, VerbindungAusbeute 20 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

2-Amino-4-phenyl-thiazole-5-carboxylic acid hydrazide (1 g, 4.3 mmol) was suspended in tetrahydrofurane (50 mL). Triethylamine (5 mL, 40 mmol) and carbonyldiimidazole (0.83, 5.1 mmol) was added. The reaction mixture was stirred at room temperature for 1 h. The solvent was removed in vacuo. The crude product was purified by flash column chromatography, eluted with the ethyl acetate/hexanes (1/1) to give the product as a solid. Yield: 20%.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customThe crude product was purified by flash column chromatography
  3. washeluted with the ethyl acetate/hexanes (1/1)

Quellen und Nachweise

ORD-Eintrag
ord-0f6bc6830d7c4a508f5a3bf6d5c4a137
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07910613B2

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