Hydrochloric Acid → 3-Bromo-6-chloro-2-methylpyridine

HRID 604606

Reaktionsgleichung

Reaktionsgleichung von HRID 604606
N([O-])=O.[Na+].N[C:6]1[N:11]=[C:10]([CH3:12])[C:9]([Br:13])=[CH:8][CH:7]=1.[ClH:14]>>[Br:13][C:9]1[C:10]([CH3:12])=[N:11][C:6]([Cl:14])=[CH:7][CH:8]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 1706782-Pyridinamine, 5-bromo-6-methyl-HCID 23668193Sodium Nitrite

Produkt 1

HCID 148666743-Bromo-6-chloro-2-methylpyridine

Versuchsvorschrift

Sodium nitrite (4.5 g, 66 mmol) was added slowly to a solution of 6-amino-3-bromo-2-methylpyridine (3.07 g, 16.4 mmol) in concentrated HCl (40 mL) at −20° C. After 1 h, the reaction was allowed to warm to room temperature and stirred overnight. The reaction was carefully neutralized with ice-cold 5N NaOH until pH=11. The aqueous layer was extracted with Et2O (3×75 mL). The combined organic layers were washed with brine (1×75 mL), dried (Na2SO4) and concentrated in vacuo to afford 3-bromo-6-chloro-2-methylpyridine, as a white solid, which was used in the next step without further purification. LCMS calc.=205.9; found=206.0 (M+1)+. 1H NMR (500 MHz, CDCl3) δ 7.76 (d, J=8.2 Hz, 1H); 7.07 (d, J=8.1 Hz, 1H); 2.66 (s, 3H).

Aufarbeitung

  1. extractionThe aqueous layer was extracted with Et2O (3×75 mL)
  2. washThe combined organic layers were washed with brine (1×75 mL)
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ac6e33aabc464d788e16e78f17493ab2
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07910592B2

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