N'-(3-Cyano-6-methyl-pyridin-2-yl)-N,N-dimethyl-formamidine → N-(4-Bromo-phenyl)-4-(4-hydroxy-phenylsulfanyl)-3-(7-methyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzamide
Reaktionsgleichung
[NH2:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[S:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=1)[C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][CH:9]=1)=[O:6].C([C:28]1[C:29]([N:35]=[CH:36][N:37]([CH3:39])C)=[N:30][C:31]([CH3:34])=[CH:32][CH:33]=1)#N>>[Br:14][C:11]1[CH:12]=[CH:13][C:8]([NH:7][C:5](=[O:6])[C:4]2[CH:15]=[CH:16][C:17]([S:18][C:19]3[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=3)=[C:2]([NH:1][C:39]3[C:28]4[CH:33]=[CH:32][C:31]([CH3:34])=[N:30][C:29]=4[N:35]=[CH:36][N:37]=3)[CH:3]=2)=[CH:9][CH:10]=1Komponenten
3
Versuchsvorschrift
The product of Example 28A was reacted with the product of Example 9B using the procedure of Example 22C substituting the product of Example 28A for the product of Example 22B and substituting the product of Example 9B for the product of Example 8E to provide the crude title compound which was purified by column chromatography on silica gel using methanol/dichloromethane as eluent to provide the title product (24 mg, 51%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 2.68 (s, 3 H) 6.85 (d, J=8.46 Hz, 2 H) 6.89-7.00 (m, 1 H) 7.31 (d, J=8.82 Hz, 2 H) 7.45-7.64 (m, 3 H) 7.67-7.88 (m, 3 H) 7.97 (s, 1 H) 8.58 (s, 1 H) 8.70-8.92 (m, 1 H) 9.96 (s, 1 H) 10.19 (s, 1 H) 10.29 (s, 1 H); MS (ESI+) m/z 558/560 (M+H)+.
Aufarbeitung
- customto provide the crude title compound which
- customwas purified by column chromatography on silica gel
Quellen und Nachweise
- ORD-Eintrag
- ord-ded0380bdc59480eb3acc101f76e1784
- Quelldatensatz
- uspto-grants-2011_03
- Patentnummer
- US07910595B2
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