Trifluoroacetic acid → Trifluoroacetic acid

HRID 605116Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 605116
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([S:14][C:15]2[CH:20]=[CH:19][C:18]([C:21](=[O:30])[NH:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([Br:29])[CH:24]=3)=[CH:17][C:16]=2[NH:31][C:32]2[C:33]3[CH:41]=[CH:40][C:39]([CH3:42])=[N:38][C:34]=3[N:35]=[CH:36][N:37]=2)=[CH:10][CH:9]=1)(C)(C)C.[F:44][C:45]([F:50])([F:49])[C:46]([OH:48])=[O:47]>C(Cl)Cl>[NH2:7][C:8]1[CH:13]=[CH:12][C:11]([S:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([NH:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([Br:29])[CH:24]=3)=[O:30])=[CH:17][C:16]=2[NH:31][C:32]2[C:33]3[CH:41]=[CH:40][C:39]([CH3:42])=[N:38][C:34]=3[N:35]=[CH:36][N:37]=2)=[CH:10][CH:9]=1.[F:44][C:45]([F:50])([F:49])[C:46]([OH:48])=[O:47]

Komponenten

5

Edukt 2

HCID 6422Trifluoroacetic acidHCID 67040669{4-[4-(3-Bromo-phenylcarbamoyl)-2-(7-methyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenyl}-carbamic acid tert-butyl ester

Produkt 2

HCID 6422Trifluoroacetic acidHCID 670409784-(4-Amino-phenylsulfanyl)-N-(3-bromo-phenyl)-3-(7-methyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The product of Example 66 was treated with trifluoroacetic acid (3 mL) in methylene chloride (3 mL) at room temperature for 30 minutes. The solvents were removed under vacuum to provide the title compound as a trifluoroacetic acid salt. 1H NMR (300 MHz, DMSO-D6) δ ppm: 2.77 (s, 3 H) 6.65 (d, J=8.46 Hz, 2 H) 6.97 (d, J=8.46 Hz, 1 H) 7.16 (d, J=8.46 Hz, 2 H) 7.30 (m, 2 H) 7.72 (m, 1 H) 7.90 (m, 3 H) 8.05 (s, 1 H) 8.92 (s, 1 H) 9.01 (d, J=8.46 Hz, 1 H) 10.36 (s, 1 H) 11.78 (s, 1 H); MS (ESI+) m/z 557, 559 (M+H)+.

Aufarbeitung

  1. customThe solvents were removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-b81b2b9de656449287c14953131a8f83
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07910595B2

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