3-Bromo-N-[5-(4-hydroxy-phenylsulfanyl)-2-methyl-4-nitro-phenyl]-benzamide → N-[4-Amino-5-(4-hydroxy-phenylsulfanyl)-2-methyl-phenyl]-3-bromo-benzamide

HRID 605291Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 605291
[Br:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][CH:28]=1)[C:5]([NH:7][C:8]1[CH:13]=[C:12]([S:14][C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)[C:11]([N+:22]([O-])=O)=[CH:10][C:9]=1[CH3:25])=[O:6].OC1C=CC(SC2C([N+]([O-])=O)=CC(C)=C(NC(=O)CC3C=CC=CC=3)C=2)=CC=1>>[NH2:22][C:11]1[C:12]([S:14][C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)=[CH:13][C:8]([NH:7][C:5](=[O:6])[C:4]2[CH:26]=[CH:27][CH:28]=[C:2]([Br:1])[CH:3]=2)=[C:9]([CH3:25])[CH:10]=1

Komponenten

3

Edukt 2

HCID 670402513-Bromo-N-[5-(4-hydroxy-phenylsulfanyl)-2-methyl-4-nitro-phenyl]-benzamide2×HCID 67041085N-[5-(4-Hydroxy-phenylsulfanyl)-2-methyl-4-nitro-phenyl]-2-phenyl-acetamide

Produkt 1

HCID 67040607N-[4-Amino-5-(4-hydroxy-phenylsulfanyl)-2-methyl-phenyl]-3-bromo-benzamideAusbeute 86 %

Versuchsvorschrift

The product from Example 266B was reacted according to the procedure from Example 265C substituting the product from Example 266B for the product from Example 265B to provide the title compound as a brown solid (0.164 g, 86%). This material was utilized without purification by silica gel chromatography.

Quellen und Nachweise

ORD-Eintrag
ord-e534153dea784af89212a3a177600d82
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07910595B2

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