Hydrochloric Acid → 4-(4-Amino-phenoxy)-N-(4-bromo-phenyl)-3-nitro-benzamide

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of the product from Example 10A (3.55g, 10 mmol), 4-aminophenol (1.09 g, 10 mmol), and potassium hydroxide (1.12 g, 20 mmol) were dissolved in dimethyl sulfoxide (15 mL) and heated at 100° C. in a CEM Discover microwave for 25 minutes. The mixture was then cooled to room temperature, poured into water (300 mL), the pH of the solution adjusted to 6 with 1N aqueous hydrochloric acid, the resultant solution stirred for 30 minutes and the resultant solid collected and dried to provide the title compound as a yellow solid (4.2 g, 98%).

Herkunft & Nachweise