HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(S)-(-)-N,alpha-Dimethylbenzylamine → (S)-(4-{2-(7-Isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-[methyl-(1-phenyl-ethyl)-carbamoyl]-phenylsulfanyl}-phenyl)-carbamic acid tert-butyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (S)-(-)-N,alpha-Dimethylbenzylamine | HCID 2060073 | — |
| Edukt | 4-(4-tert-Butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid | HCID 59376892 | — |
| Produkt | (S)-(4-{2-(7-Isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-[methyl-(1-phenyl-ethyl)-carbamoyl]-phenylsulfanyl}-phenyl)-carbamic acid tert-butyl ester | HCID 67040484 | 54% |
Reaktionsschritte
According to the procedure in Example 385F, the title compound was prepared using 4-(4-tert-butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid (prepared in Example 385E) and (S)-N,α-dimethylbenzylamine: yield 54%.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07910595B2 |
| Quelldatensatz | uspto-grants-2011_03 |
| ORD ID | ord-bd8c6c82429c418099117afb3d68214f |
| Quellennotiz | uspto-grants-2011_03 |