4-(4-tert-Butoxycarbonylamino-phenylsulfanyl)-3-nitro-benzoic acid methyl ester → Methyl 3-amino-4-(4-(methoxycarbonylamino)phenylthio)benzoate

HRID 605402Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 605402
[CH3:1][O:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([S:12][C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][C:14]=2[N+:23]([O-])=O)=[CH:8][CH:7]=1)=[O:4].COC(=O)C1C=CC(SC2C=CC(NC(OC(C)(C)C)=O)=CC=2)=C([N+]([O-])=O)C=1>>[NH2:23][C:14]1[CH:15]=[C:16]([CH:21]=[CH:22][C:13]=1[S:12][C:9]1[CH:10]=[CH:11][C:6]([NH:5][C:3]([O:2][CH3:1])=[O:4])=[CH:7][CH:8]=1)[C:17]([O:19][CH3:20])=[O:18]

Komponenten

3

Edukt 2

HCID 593768704-(4-tert-Butoxycarbonylamino-phenylsulfanyl)-3-nitro-benzoic acid methyl esterHCID 67041007Methyl 4-(4-(methoxycarbonylamino)phenylthio)-3-nitrobenzoate

Produkt 1

HCID 67040749Methyl 3-amino-4-(4-(methoxycarbonylamino)phenylthio)benzoateAusbeute 88 %

Versuchsvorschrift

The title compound was prepared by the procedure in Example 385C substituting the product from Example 441A for the product of Example 385B. The reaction was purified by silica gel chromatography (ethyl acetate/CHCl3=1/9) to give the title compound (yield 88%).

Aufarbeitung

  1. customThe title compound was prepared by the procedure in Example 385C
  2. customThe reaction was purified by silica gel chromatography (ethyl acetate/CHCl3=1/9)

Quellen und Nachweise

ORD-Eintrag
ord-e156897df9164f93ad499a016bae9f56
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07910595B2

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