Potassium Iodide → 4-[(Ethylpropylamino)methyl]benzenemethanol

HRID 605579Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 605579
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][OH:10])=[CH:5][CH:4]=1.[CH2:11]([NH:13][CH2:14][CH2:15][CH3:16])[CH3:12].[I-].[K+].C([O-])([O-])=O.[K+].[K+]>C(#N)C>[CH2:11]([N:13]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][OH:10])=[CH:5][CH:4]=1)[CH2:14][CH2:15][CH3:16])[CH3:12]

Komponenten

6

Edukt 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 883981-Propanamine, N-ethyl-HCID 5107660[4-(Chloromethyl)phenyl]methanol

Produkt 1

HCID 866357944-[(Ethylpropylamino)methyl]benzenemethanolAusbeute 52,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A mixture of 5 g of [4-(chloromethyl)phenyl]methanol, 5.56 g of N-ethylpropan-1-amine, 5.29 g of potassium iodide and 4.41 g of K2CO3 in 200 ml of acetonitrile is left to stir at AT for 48 hours. The reaction mixture is concentrated under vacuum, the residue is taken up with water, the mixture is extracted with DCM, the organic phase is dried over Na2SO4, and the solvent is evaporated off under vacuum. 3.5 g of the expected compound are obtained.

Aufarbeitung

  1. waitis left
  2. concentrationThe reaction mixture is concentrated under vacuum
  3. extractionthe mixture is extracted with DCM
  4. dry with materialthe organic phase is dried over Na2SO4
  5. customthe solvent is evaporated off under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-c40dd9c3b98f4a65bbec09837094493d
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07915258B2

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