Methylamine → 4-Bromo-N-methylthiazole-2-carboxamide

HRID 605945Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 605945
C([O:3][C:4]([C:6]1[S:7][CH:8]=[C:9]([Br:11])[N:10]=1)=O)C.[CH3:12][NH2:13]>CO>[CH3:12][NH:13][C:4]([C:6]1[S:7][CH:8]=[C:9]([Br:11])[N:10]=1)=[O:3]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 49757955Ethyl 4-bromothiazole-2-carboxylate

Produkt 1

HCID 575900864-Bromo-N-methylthiazole-2-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

4-Bromothiazole-2-carboxylic acid ethyl ester (500 mg, 2.13 mmol) is dissolved in methanol (1 mL) and methyl amine in methanol (10 mL) is added. The mixture is stirred overnight at room temperature. Evaporation of the solvent under reduced pressure affords the title compound as yellow solid. LCMS: Rt 0.92 min (100%) m/z (ESI) 219/221 (M+H)+.

Aufarbeitung

  1. customEvaporation of the solvent under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1ac158033ba34f7089024cf60db846ad
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07915256B2

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