Acetic Anhydride → (4-Bromopyridin-2-yl)methyl acetate

HRID 605957

Reaktionsgleichung

Reaktionsgleichung von HRID 605957
[Br:1][C:2]1[CH:7]=[CH:6][N+:5]([O-])=[C:4]([CH3:9])[CH:3]=1.[C:10]([O:13]C(=O)C)(=[O:12])[CH3:11]>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:9][O:13][C:10](=[O:12])[CH3:11])[CH:3]=1

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 544461394-Bromo-2-methyl-1-oxo-1lambda~5~-pyridine

Produkt 1

HCID 45789873(4-Bromopyridin-2-yl)methyl acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 4-bromo-2-methylpyridine-1-oxide (4.00 g, 21.40 mmol) in DCM (20 mL) is added acetic anhydride (6 mL). The mixture is stirred at room temperature for 1 hour and then heated at reflux overnight. The solvent is removed under vacuum and the crude product is filtered through a silica plug, eluting with DCM to afford the title compound as an orange oil (815 mg).

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux overnight
  3. customThe solvent is removed under vacuum
  4. filtrationthe crude product is filtered through a silica plug
  5. washeluting with DCM

Quellen und Nachweise

ORD-Eintrag
ord-38636f2731b94ebe82902bd00ee169fc
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07915256B2

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