2-Benzofurancarboxylic acid, 5-methoxy-, ethyl ester → Ethyl 5-hydroxybenzofuran-2-carboxylate

HRID 606580

Reaktionsgleichung

Reaktionsgleichung von HRID 606580
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:8][C:7]=2[CH:16]=1>ClCCl>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:8][C:7]=2[CH:16]=1

Komponenten

3

Edukt 1

HCID 5212832-Benzofurancarboxylic acid, 5-methoxy-, ethyl ester

Produkt 1

HCID 22228632Ethyl 5-hydroxybenzofuran-2-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

Ethyl 5-methoxybenzofuran carboxylate (22.7 mmol) was dissolved in dichlormethane (20 ml) and a 1.0 M solution of boron tribromide methyl sulphide complex in dichloromethane (68.1 mmol) was added. The mixture was heated at reflux over night The solvent was evaporated under vacuo and the residue purified by flash chromatography to obtain ethyl 5-hydroxybenzofuran carboxylate as a white solid.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureat reflux over night The solvent
  3. customwas evaporated under vacuo
  4. customthe residue purified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-9919d0ed1faa48e0997bfb8a70d6c37d
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07915300B2

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