HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 606792Erstellt: 24. Oktober 2026
Triethylamine → 1-[(Trimethylsilyl)ethynyl]-3-(trifluoromethyl)benzene
https://huagongshe.com/de/reaction/606792
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | Benzene, 1-bromo-3-(trifluoromethyl)- | HCID 9817 | — |
| Edukt | Trimethylsilylacetylene | HCID 66111 | — |
| Katalysator | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Katalysator | HCID 178419050 | HCID 178419050 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | 1-[(Trimethylsilyl)ethynyl]-3-(trifluoromethyl)benzene | HCID 4281885 | 102,2% |
Reaktionsschritte
Add copper (I) iodide (48.2 mg, 0.25 mmol), bis(triphenylphosphine)palladium (II) dichloride (155.8 m g, 0.22 mmol) and triethylamine (2.51 mL, 17.8 mmol), to a solution of 1-bromo-3-trifluoromethylbenzene (0.62 mL, 4.44 mmol) and trimethylsilylacetylene (0.81 mL, 5.78 mmol), in ethyl acetate (4 mL). Stir at 50° C. for 18h. Cool the reaction mixture to room temperature, concentrate and purify the residue by silica gel chromatography, eluting with hexanes, to give the title compound (1.1 g, 100%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US07915424B2 |
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| Quelldatensatz | uspto-grants-2011_03 |
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| ORD ID | ord-f63577125a7149d4866ada36ec1221d8 |
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| Quellennotiz | uspto-grants-2011_03 |
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