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Iodine → Benzyl 5-(3-iodo-4-methoxyphenyl)-6-methylpyridine-2-carboxylate

HRID 607072
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 607072
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])=[N:13][C:14]=2[CH3:15])=[CH:5][CH:4]=1.[I:26]I>CO.S([O-])([O-])(=O)=O.[Ag+2]>[I:26][C:8]1[CH:7]=[C:6]([C:9]2[CH:10]=[CH:11][C:12]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])=[N:13][C:14]=2[CH3:15])[CH:5]=[CH:4][C:3]=1[O:2][CH3:1]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

5

Edukt 2

HCID 807Iodine2×HCID 57704814Benzyl 5-(4-methoxyphenyl)-6-methylpyridine-2-carboxylate

Produkt 1

HCID 57704790Benzyl 5-(3-iodo-4-methoxyphenyl)-6-methylpyridine-2-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418844HCID 178418844, VerbindungKatalysator2×HCID 887MethanolLösungsmittel

Versuchsvorschrift

Benzyl 5-(4-methoxyphenyl)-6-methylpyridine-2-carboxylate (150 mg, 0.45 mmol), iodine (228 mg, 0.898 mmol), silver sulfate (402 mg, 1.29 mmol) were stirred in methanol (3 mL) at room temperature overnight. More iodine (57 mg, 0.22 mmol) and silver sulfate (100 mg, 0.32 mmol) were added into reaction mixture after 25 hours. Added aqueous NaHSO3 solution (sat., 20 mL) into the reaction mixture after additional 1.5 hours to quench the reaction. The reaction mixture was extracted with ethyl acetate. The combined extracts were dried over Na2SO4 followed by filtration and concentration to afford a clear oil. The crude oil was purified by preparative TLC on SiO2 (eluted with 30% ethyl acetate in hexanes) to afford benzyl 5-(3-iodo-4-methoxyphenyl)-6-methylpyridine-2-carboxylate. LCMS calc.=459.03; found=460.17 (M+1)+.

Aufarbeitung

  1. customAdded aqueous NaHSO3 solution (sat., 20 mL) into the reaction mixture after additional 1.5 hours to quench
  2. customthe reaction
  3. extractionThe reaction mixture was extracted with ethyl acetate
  4. dry with materialThe combined extracts were dried over Na2SO4
  5. filtrationfollowed by filtration and concentration
  6. customto afford a clear oil
  7. customThe crude oil was purified by preparative TLC on SiO2 (eluted with 30% ethyl acetate in hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-f98947ce021f48c097610ef4fef6f949
Quelldatensatz
uspto-grants-2011_03
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US07915271B2

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