N-[4-(2-Amino-4-methyl-phenylsulfanyl)-phenyl]-acetamide → N-[4-[2-[(7-cyclopropylpyrido[2,3-d]pyrimidin-4-yl)amino]-4-methyl-phenyl]sulfanylphenyl]acetamide

HRID 607229Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 607229
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[S:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:19])[CH3:18])=[CH:12][CH:11]=1.C([C:22]1[C:23]([N:31]=[CH:32][N:33]([CH3:35])C)=[N:24][C:25]([CH:28]2[CH2:30][CH2:29]2)=[CH:26][CH:27]=1)#N.NC1C=C(C)C=CC=1SC1C=CC(O)=CC=1.C(C1C(N=CN(C)C)=NC(C)=CC=1)#N>>[CH:28]1([C:25]2[CH:26]=[CH:27][C:22]3[C:35]([NH:1][C:2]4[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=4[S:9][C:10]4[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:19])[CH3:18])=[CH:12][CH:11]=4)=[N:33][CH:32]=[N:31][C:23]=3[N:24]=2)[CH2:29][CH2:30]1

Komponenten

5

Edukt 4

HCID 43168935N-[4-(2-Amino-4-methyl-phenylsulfanyl)-phenyl]-acetamide2×HCID 668081234-(2-Amino-4-methyl-phenylsulfanyl)-phenolHCID 66808412N'-(3-Cyano-6-cyclopropyl-pyridin-2-yl)-N,N-dimethyl-formamidine2×HCID 66808573N'-(3-Cyano-6-methyl-pyridin-2-yl)-N,N-dimethyl-formamidine

Produkt 1

HCID 57394885N-[4-[2-[(7-cyclopropylpyrido[2,3-d]pyrimidin-4-yl)amino]-4-methyl-phenyl]sulfanylphenyl]acetamide

Versuchsvorschrift

The product from Example 7b was reacted with the product from Example 119A using the procedure from Example 102 substituting the product from Example 7b for the product from Example 6c and substituting the product from Example 119A for the product from Example 10B to provide the crude residue which was purified by trituration with methanol to provide the title compound. 1H NMR (300 MHz, DMSO-D6) δ ppm: 1.13 (d, J=6.25 Hz, 4H), 2.02 (s, 3H), 2.22-2.38 (m, 1H), 2.31 (s, 3H), 7.07 (s, 2H), 7.20 (d, J=8.82 Hz, 2H), 7.30 (s, 1H), 7.50 (d, J=8.82 Hz, 2H), 7.56 (d, J=8.46 Hz, 1H), 8.49 (s, 1H), 8.68 (d, J=8.82 Hz, 1H), 9.99 (s, 2H); MS (ESI+) m/z 442 (M+H)+.

Aufarbeitung

  1. customto provide the crude residue which
  2. customwas purified by trituration with methanol

Quellen und Nachweise

ORD-Eintrag
ord-05107f435f354978aaffea2af132e178
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07915411B2

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