Dimethylformamide dimethyl acetal → N'-(3-Cyano-6-isopropyl-pyrazin-2-yl)-N,N-dimethyl-formamidine

HRID 607328Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 607328
[NH2:1][C:2]1[C:3]([C:11]#[N:12])=[N:4][CH:5]=[C:6]([CH:8]([CH3:10])[CH3:9])[N:7]=1.CO[CH:15](OC)[N:16]([CH3:18])[CH3:17]>C1(C)C=CC=CC=1>[C:11]([C:3]1[C:2]([N:1]=[CH:15][N:16]([CH3:18])[CH3:17])=[N:7][C:6]([CH:8]([CH3:10])[CH3:9])=[CH:5][N:4]=1)#[N:12]

Komponenten

4

Edukt 2

HCID 78373Dimethylformamide dimethyl acetalHCID 451224093-Amino-5-isopropylpyrazine-2-carbonitrile

Produkt 1

HCID 66808405N'-(3-Cyano-6-isopropyl-pyrazin-2-yl)-N,N-dimethyl-formamidineAusbeute 100,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of the product from Example 244B (0.37 g, 2.28 mmol) and dimethylformamide dimethylacetal (0.30 g, 2.5 mmol, 1.1 eq) in toluene (25 mL) was heated under reflux for 1.75 h. The reaction mixture was then cooled to room temperature and the solvent evaporated under reduced pressure to provide the title compound (0.50 g, 100%) as a thick red/brown oil that was used in subsequent reactions without further purification.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 1.75 h
  3. customthe solvent evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-85a837887aca4eb4bebd7c9770ff41fd
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07915411B2

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