Hydrogen Bromide → Methyl 2-fluoro-4-(oxoacetyl)benzoate

HRID 607605Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 607605
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([F:14])[CH:5]=1)(=[O:3])[CH3:2].Br.CS(C)=[O:18]>>[F:14][C:6]1[CH:5]=[C:4]([C:1](=[O:3])[CH:2]=[O:18])[CH:13]=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]

Komponenten

4

Edukt 3

HCID 260Hydrogen BromideHCID 679Dimethyl SulfoxideHCID 59216348Methyl 4-acetyl-2-fluorobenzoate

Produkt 1

HCID 59216303Methyl 2-fluoro-4-(oxoacetyl)benzoate

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of methyl 4-acetyl-2-fluorobenzoate (1.6 g, 0.0082 mol), 48% of hydrogen bromide aqueous solution (2.8 mL) in dimethyl sulfoxide (20 mL) was stirred at 60° C. overnight. After cooling, the mixture was poured into ice-water. The product was extracted with ethyl ether. The combined extracts were washed with brine; dried over Na2SO4, filtered concentrated to yield 1.60 g of the product which was directly used in the next step without further purification.

Aufarbeitung

  1. temperatureAfter cooling
  2. extractionThe product was extracted with ethyl ether
  3. washThe combined extracts were washed with brine
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-f55fead6550c4dcd8c1399cc4480f337
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07915408B2

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