Methanol → Methyl 2-bromo-5-methylbenzoate

HRID 60888

Reaktionsgleichung

Reaktionsgleichung von HRID 60888
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].OS(O)(=O)=O.[CH3:17]O>>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([O:6][CH3:17])=[O:5]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 2280802-Bromo-5-methylbenzoic acid

Produkt 1

HCID 15110996Methyl 2-bromo-5-methylbenzoate

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

2-Bromo-5-methylbenzoic acid (9.3 g, 43.4 mmol) was dissolved in MeOH (100 mL) and then cat. conc. H2SO4 was added. The mixture was refluxed at 100° C. overnight. The mixture was cooled to rt and the solvent was removed at reduced pressure. The crude residue was dissolved with EtOAc, and washed with water twice, followed by saturated NaHCO3 and brine, dried over anhydrous Na2SO4. The solvent was removed in vacuo to obtain the title compound with no further purification.

Aufarbeitung

  1. temperatureThe mixture was cooled to rt
  2. customthe solvent was removed at reduced pressure
  3. dissolutionThe crude residue was dissolved with EtOAc
  4. washwashed with water twice
  5. dry with materialdried over anhydrous Na2SO4
  6. customThe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f3beddf5a050465f840bd0014af2be0c
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09440982B2

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