2-Methoxy-2,4,6-cycloheptatrien-1-one → 2-(4-Piperonyl-1-piperazinyl)-2,4,6-cycloheptatriene-1-one

HRID 609584

Reaktionsgleichung

Reaktionsgleichung von HRID 609584
CO[C:3]1[C:9](=[O:10])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:11]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[C:12]1[CH:20]=[CH:19][C:18]2[O:17][CH2:16][O:15][C:14]=2[CH:13]=1>CO>[CH2:11]([N:21]1[CH2:26][CH2:25][N:24]([C:3]2[C:9](=[O:10])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH2:23][CH2:22]1)[C:12]1[CH:20]=[CH:19][C:18]2[O:17][CH2:16][O:15][C:14]=2[CH:13]=1

Komponenten

4

Edukt 2

HCID 165462-Methoxy-2,4,6-cycloheptatrien-1-oneHCID 944261-Piperonylpiperazine

Produkt 1

HCID 98402272-(4-Piperonyl-1-piperazinyl)-2,4,6-cycloheptatriene-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 2-methoxytropone (1.36 g, 10.0 mmol) (Pietra, F. Chem Review, 1973, 73:293) and 1-piperonylpiperazine (6.61 g, 30.0 mmol) in methanol (50.0 mL) was refluxed for 16 h. After cooling to room temperature, the solvent was removed in vacuo. The residue was subjected to column chromatography using ethyl acetate as the eluent. The title compound was obtained as a yellow oil (1.24 g, 38%). MS (FAB) 325 (M+ +1).

Aufarbeitung

  1. temperaturewas refluxed for 16 h
  2. customthe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-cff103170fa347b5a3c1344cde5b35a5
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US05998414

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