Potassium Carbonate → N-[(1-Benzyl-4-piperidyl)methy] 3,4-dihydro-2 H-[1,3]oxazino[3,2-a]indole-10-Carboxamide

HRID 609596Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 609596
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][CH:19]=2)=[O:17])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:28][CH2:29][CH2:30][OH:31].C([O-])(O)=O.[Na+].C(=O)([O-])[O-].[K+].[K+]>C(Cl)(Cl)Cl>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([C:18]2[C:26]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[N:20]3[CH2:28][CH2:29][CH2:30][O:31][C:19]=23)=[O:17])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

6

Edukt 4

HCID 11430Potassium CarbonateHCID 123083-Bromo-1-propanolHCID 516892Sodium BicarbonateHCID 19599446N-[(l-benzyl-4-piperidyl)methyl] indole-3-carboxamide

Produkt 1

HCID 19599417N-[(1-Benzyl-4-piperidyl)methy] 3,4-dihydro-2 H-[1,3]oxazino[3,2-a]indole-10-CarboxamideAusbeute 15,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A stirred suspension of N-[(1-benzyl-4-piperidyl)methyl] indole-3-carboxamide (17.5g, 0.050 mole) in chloroform (250 ml) was treated with 3-bromo-1-propanol (10.1 ml, 0.11 mole) and N-chlorosuccinimde (8.7g. 0.065 mole) at room temperature and a clear solution was obtained in 15 minutes. After 1 h the reaction mixture darkened in colour from pale yellow to orange and temperature rose to 38° C. After a further 1 h the reaction mixture was treated with 10% NaHCO3 solution and the chloroform layer separated, dried (Na2SO4) and concentrated in lvacuo to leave a yellow oil, which was chromatographed on silica gel eluting with 3% methanol/chloroform. The 2-(3-bromopropoxy)indole intermediate was dissolved in acetone (400 ml), treated with anhydrous potassium carbonate (11 g, 0.80 mole) and stirred at room temperature for 20 h. The reaction mixture was concentrated in vicuo and the residue treated with water (200 ml) and extracted with chloroform (2×250 ml). The combined extracts were dried (Na2SO4), concentrated in vacuo and the residue chromatographed on silica gel eluting with 5% methanol/chloroform to afford the title compound (E20) as a pale yellow oil (3.1 g, 15%). This was converted to its oxalate salt and crystallised from acetone as a white solid mp 169-170° C.

Aufarbeitung

  1. customa clear solution was obtained in 15 minutes
  2. customrose to 38° C
  3. customthe chloroform layer separated
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated in lvacuo
  6. customto leave a yellow oil, which
  7. customwas chromatographed on silica gel eluting with 3% methanol/chloroform
  8. dissolutionThe 2-(3-bromopropoxy)indole intermediate was dissolved in acetone (400 ml)
  9. concentrationThe reaction mixture was concentrated in vicuo
  10. additionthe residue treated with water (200 ml)
  11. extractionextracted with chloroform (2×250 ml)
  12. dry with materialThe combined extracts were dried (Na2SO4)
  13. concentrationconcentrated in vacuo
  14. customthe residue chromatographed on silica gel eluting with 5% methanol/chloroform

Quellen und Nachweise

ORD-Eintrag
ord-75de28adafed4137a125bccee2e53de4
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US05998409

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