3-Amino-N-(4-bromophenyl)benzamide → 5-Benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid [3-(4-bromo-phenylcarbamoyl)-phenyl]-amide

HRID 610068

Reaktionsgleichung

Reaktionsgleichung von HRID 610068
C(O[C:4]([CH:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:15](=[O:22])[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:13]=2)[N:8]([CH2:23][CH3:24])[C:7]1=[O:25])=[O:5])C.[NH2:26][C:27]1[CH:28]=[C:29]([CH:40]=[CH:41][CH:42]=1)[C:30]([NH:32][C:33]1[CH:38]=[CH:37][C:36]([Br:39])=[CH:35][CH:34]=1)=[O:31]>>[Br:39][C:36]1[CH:37]=[CH:38][C:33]([NH:32][C:30]([C:29]2[CH:28]=[C:27]([NH:26][C:4]([CH:6]3[C:14]4[C:9](=[CH:10][CH:11]=[C:12]([C:15](=[O:22])[C:16]5[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=5)[CH:13]=4)[N:8]([CH2:23][CH3:24])[C:7]3=[O:25])=[O:5])[CH:42]=[CH:41][CH:40]=2)=[O:31])=[CH:34][CH:35]=1

Komponenten

3

Edukt 2

HCID 136095143-Amino-N-(4-bromophenyl)benzamideHCID 20189466Ethyl 1-ethyl-5-benzoyloxindole-3-carboxylate

Produkt 1

HCID 541779685-Benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid [3-(4-bromo-phenylcarbamoyl)-phenyl]-amide

Versuchsvorschrift

Prepared as in Example 1, Step A, from 5-benzoyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid ethyl ester (U.S. Pat. No. 4,686,224) and 3-amino-N-(4-bromo-phenyl)-benzamide. Purified by flash-chromatography (hexanes/acetone, 1:1) followed by trituration in ethyl acetate/hexanes. mp 139-142° C.

Aufarbeitung

  1. customPrepared as in Example 1, Step A
  2. customPurified by flash-chromatography (hexanes/acetone, 1:1)

Quellen und Nachweise

ORD-Eintrag
ord-5135fb3f47c14e0582bed7be8351239d
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US05998463

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