3-Aminobenzanilide → 1-Ethyl-2-oxo-5-propionyl-2,3-dihydro-1H-indole-3-carboxylic acid (3-phenylcarbamoyl-phenyl)-amide
Reaktionsgleichung
CO[C:3]([CH:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:14]3([CH2:19][CH3:20])[O:18]CCO3)[CH:12]=2)[N:7]([CH2:21][CH3:22])[C:6]1=[O:23])=[O:4].[NH2:24][C:25]1[CH:26]=[C:27]([CH:37]=[CH:38][CH:39]=1)[C:28]([NH:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:29]>>[C:31]1([NH:30][C:28]([C:27]2[CH:26]=[C:25]([NH:24][C:3]([CH:5]3[C:13]4[C:8](=[CH:9][CH:10]=[C:11]([C:14](=[O:18])[CH2:19][CH3:20])[CH:12]=4)[N:7]([CH2:21][CH3:22])[C:6]3=[O:23])=[O:4])[CH:39]=[CH:38][CH:37]=2)=[O:29])[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1Komponenten
3
Versuchsvorschrift
Prepared as in Example 1 from 1-ethyl-5-(2-ethyl-[1,3]dioxolan-2-yl)-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester and 3-amino-N-phenyl-benzamide. Purified by flash-chromatography (chloroform/methanol, 20:1) followed by trituration in hexanes/ethyl acetate. mp 179-180° C.
Aufarbeitung
- customPurified by flash-chromatography (chloroform/methanol, 20:1)