Methyl chloroformate → Benzoic acid, 4-(1-methylethenyl)-, methyl ester

HRID 610105

Reaktionsgleichung

Reaktionsgleichung von HRID 610105
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([CH3:8])=[CH2:7])=[CH:4][CH:3]=1.[Mg].Cl[C:13]([O:15][CH3:16])=[O:14]>C1COCC1>[C:6]([C:5]1[CH:9]=[CH:10][C:2]([C:13]([O:15][CH3:16])=[O:14])=[CH:3][CH:4]=1)([CH3:8])=[CH2:7]

Komponenten

5

Edukt 3

HCID 6586Methyl chloroformateHCID 743814-Chloro-alpha-methylstyreneHCID 5462224Magnesium

Produkt 1

HCID 11275336Benzoic acid, 4-(1-methylethenyl)-, methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Preparation of the Grignard compound of 4-chloro-α-methylstyrene by means of Rieke magnesium in THF under reflux and subsequent reaction with 0.95 equivalents of methyl chloroformate at RT. Aqueous working up, extraction with ethyl acetate and column chromatography using cyclohexane/ethyl acetate 85:15 affords methyl 4-isopropenylbenzoate as colorless crystals.

Aufarbeitung

  1. temperatureunder reflux
  2. extractionextraction with ethyl acetate and column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-0c66f3c754bd40ea943d24950051c2a9
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US05998481

Verknüpfte Notizen

Wird geladen…