3-Phenylsalicylic acid → 2-(2,4-Dimethyl-3-pentyloxy)carbonyl-6-phenylphenol

HRID 610459

Reaktionsgleichung

Reaktionsgleichung von HRID 610459
CS([O:5][CH:6]([CH:10]([CH3:12])[CH3:11])[CH:7]([CH3:9])[CH3:8])(=O)=O.[C:13]1([C:19]2[CH:27]=[CH:26][CH:25]=[C:21]([C:22](O)=[O:23])[C:20]=2[OH:28])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O>[CH3:8][CH:7]([CH:6]([O:5][C:22]([C:21]1[CH:25]=[CH:26][CH:27]=[C:19]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:20]=1[OH:28])=[O:23])[CH:10]([CH3:12])[CH3:11])[CH3:9]

Komponenten

5

Edukt 3

HCID 93483-Phenylsalicylic acidHCID 10340Sodium CarbonateHCID 54447467(2,4-Dimethyl-3-pentyl) methanesulfonate

Produkt 1

HCID 110560652-(2,4-Dimethyl-3-pentyloxy)carbonyl-6-phenylphenolAusbeute 64 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

In a four-neck flask having an inner volume of 100 ml, 4.86 g (25 m.mols) of (2,4-dimethyl-3-pentyl) methanesulfonate, 5.36 g (25 m.mols) of 3-phenylsalicylic acid, 2.65 g (25 m.mols) of sodium carbonate, and 50 ml of dimethyl formamide were placed and left reacting at 90° C. for three hours. After the reaction, the reaction mass was thrown into 100 ml of ice water and extracted twice with 150 ml of ethyl acetate. The organic layer obtained consequently was washed twice with 50 ml of water. Then, by distilling the organic layer thereby expelling the solvent by evaporation, 5.00 g (16 m.mols) of 2-(2,4-dimethyl-3-pentyloxy)carbonyl-6-phenylphenol was obtained as the product aimed at.

Aufarbeitung

  1. customIn a four-neck flask having
  2. waitleft
  3. customAfter the reaction
  4. extractionextracted twice with 150 ml of ethyl acetate
  5. customThe organic layer obtained consequently
  6. washwas washed twice with 50 ml of water
  7. distillationThen, by distilling the organic layer
  8. customby evaporation

Quellen und Nachweise

ORD-Eintrag
ord-40d1a19b81ae45b9b295034e5f43b00b
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US05998609

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