Methanol → Methyl 2-amino-4-methylbenzoate

HRID 610761

Reaktionsgleichung

Reaktionsgleichung von HRID 610761
[NH2:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH3:17]O>>[NH2:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH3:17])=[O:5]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 753164-Methylanthranilic acid

Produkt 1

HCID 11205965Methyl 2-amino-4-methylbenzoate

Versuchsvorschrift

A mixture of 2-amino-4-methylbenzoic acid (15.0 g) and concentrated sulphuric acid (20 ml) was heated under reflux with methanol for 18 hours. After removal of the solvent the residue was dissolved in dichloromethane, basified with sodium carbonate solution and the organic phase was washed with water, dried (anhydrous magnesium sulphate) and the solvent evaporated to give methyl 2-amino-4-methylbenzoate, m.p. 41-43° C.

Aufarbeitung

  1. temperaturewas heated
  2. customAfter removal of the solvent the residue
  3. dissolutionwas dissolved in dichloromethane
  4. washthe organic phase was washed with water
  5. dry with materialdried (anhydrous magnesium sulphate)
  6. customthe solvent evaporated

Quellen und Nachweise

ORD-Eintrag
ord-fb508853e26b4053b9f31d5c61b56625
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US05998653

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