Hydrochloric Acid → N,N-dimethyl-[6-[4-(3,4-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

HRID 611289Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 611289
[CH3:1][N:2]([CH2:4][C:5]1[O:31][C:8]2[CH2:9][N:10]([C:13](=[O:30])[C:14]3[CH:19]=[CH:18][C:17]([C:20](=[O:29])[C:21]4[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([Cl:28])[CH:22]=4)=[CH:16][CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:3].Cl>CO.C(OCC)(=O)C>[ClH:27].[CH3:3][N:2]([CH2:4][C:5]1[O:31][C:8]2[CH2:9][N:10]([C:13](=[O:30])[C:14]3[CH:19]=[CH:18][C:17]([C:20](=[O:29])[C:21]4[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([Cl:28])[CH:22]=4)=[CH:16][CH:15]=3)[CH2:11][CH2:12][C:7]=2[CH:6]=1)[CH3:1]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 19599992HCID 19599992, Verbindung

Produkt 1

HCID 19600042N,N-dimethyl-[6-[4-(3,4-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

N,N-Dimethyl-[6-[4-(3,4-dichlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-ylmethyl]amine 0.153 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was then concentrated, and recrystallized from methanol-diethyl ether to yield the desired product.

Aufarbeitung

  1. concentrationThis mixture was then concentrated
  2. customrecrystallized from methanol-diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-7925c072d2cd43dcaeaac91d5fc6d634
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US05998433

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