Hydrochloric Acid → (E)-N,N-dimethyl-[5-(2,3-diphenylpropenoyl)-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine hydrochloride

HRID 611346Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 611346
[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:29])/[C:15](/[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:16]/[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:3].[ClH:30]>CO.C(OCC)(=O)C>[ClH:30].[CH3:1][N:2]([CH2:4][C:5]1[O:13][C:12]2[CH2:11][CH2:10][N:9]([C:14](=[O:29])/[C:15](/[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)=[CH:16]/[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH2:8][C:7]=2[CH:6]=1)[CH3:3]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 19600147(E)-N,N-dimethyl-[5-(2,3-diphenylpropenoyl)-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine

Produkt 1

HCID 19600146(E)-N,N-dimethyl-[5-(2,3-diphenylpropenoyl)-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

(E)-N,N-Dimethyl-[5-(2,3-diphenylpropenoyl)-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-ylmethyl]amine 0.241 g was dissolved in 2 ml of methanol; hydrogen chloride in ethyl acetate was added in excess, followed by stirring. This mixture was concentrated and washed with diethyl ether to yield the desired product.

Aufarbeitung

  1. concentrationThis mixture was concentrated
  2. washwashed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-1c20908060a24e9a8f283d8a87b7543b
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US05998433

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