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Ammonia → 5-(4-Methoxyphenyl)-7-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

HRID 611524
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 611524
Cl[C:2]1[C:3]2[C:10]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[CH:9][N:8]([CH:19]([CH3:21])[CH3:20])[C:4]=2[N:5]=[CH:6][N:7]=1.[NH3:22]>O1CCOCC1>[NH2:22][C:2]1[C:3]2[C:10]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[CH:9][N:8]([CH:19]([CH3:21])[CH3:20])[C:4]=2[N:5]=[CH:6][N:7]=1
KomponentenReaktionsbedingungenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 195974834-Chloro-7-isopropyl-5-(4-methoxyphenyl)pyrrolo[2,3-d]pyrimidine

Produkt 1

HCID 195974095-(4-Methoxyphenyl)-7-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

A mixture of 4-chloro-7-isopropyl-5-(4-methoxyphenyl)pyrrolo-[2,3-d]pyrimidine (1.6 g), concentrated ammonia (80 ml, S.G. 0.880) and 1,4-dioxane (80 ml) was heated in a pressure vessel at 120° C. for 18 hours. The mixture was cooled to ambient temperature and the solvent was removed under reduced pressure to give a solid residue which was partitioned between ethyl acetate (100 ml) and water (100 ml). The aqueous layer was extracted with ethyl acetate and the combined organic layers were washed with water, dried, filtered and evaporated to give 4-amino-7-isopropyl-5-(4-methoxyphenyl)pyrrolo[2,3-d]-pyrimidine. The structure was confirmed by 1H nmr.

Aufarbeitung

  1. temperatureThe mixture was cooled to ambient temperature
  2. customthe solvent was removed under reduced pressure
  3. customto give a solid residue which
  4. customwas partitioned between ethyl acetate (100 ml) and water (100 ml)
  5. extractionThe aqueous layer was extracted with ethyl acetate
  6. washthe combined organic layers were washed with water
  7. customdried
  8. filtrationfiltered
  9. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-f08c91fbda39413b92b0384fb5e6c2be
Quelldatensatz
uspto-grants-1999_12
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US06001839

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