Phosphorus oxychloride → 4-Chloro-5,8-dimethoxyquinoline-3-carbonitrile

HRID 612152Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 612152
O[C:2]1[C:11]2[C:6](=[C:7]([O:14][CH3:15])[CH:8]=[CH:9][C:10]=2[O:12][CH3:13])[N:5]=[CH:4][C:3]=1[C:16]#[N:17].P(Cl)(Cl)([Cl:20])=O>CN(C)C=O>[Cl:20][C:2]1[C:11]2[C:6](=[C:7]([O:14][CH3:15])[CH:8]=[CH:9][C:10]=2[O:12][CH3:13])[N:5]=[CH:4][C:3]=1[C:16]#[N:17]

Komponenten

4

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 178492555HCID 178492555, Verbindung

Produkt 1

HCID 224665354-Chloro-5,8-dimethoxyquinoline-3-carbonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideKatalysator

Versuchsvorschrift

A stirred mixture of 1.30 g of 4-hydroxy-5,8-dimethoxy-quinoline-3-carbonitrile, 10 ml of phosphorous oxychloride, and 2 drops of N,N-dimethylformamide was refluxed for 10 minutes and evaporated free of volatile matter. The residue was stirred with 50 ml of water. The product was collected and dried to give 1.74 g of 4-chloro-5,8-dimethoxy-quinoline-3-carbonitrile as a solid, mp 165-167° C.; mass spectrum (EI, m/e): M 248.0346.

Aufarbeitung

  1. temperaturewas refluxed for 10 minutes
  2. customevaporated free of volatile matter
  3. customThe product was collected
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-3ea57a47a1f8479faf477d4e9a8ebdd8
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US06002008

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