Benzoyl chloride, 3,4-dichloro- → 3,4-Dichloro-N-(5-chloro-2-hydroxy-4-nitrophenyl)benzamide

HRID 612346Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 612346
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][C:3]=1[OH:12].[Cl:13][C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][C:22]=1[Cl:23])[C:17](Cl)=[O:18]>C(OCC)(=O)C>[Cl:13][C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][C:22]=1[Cl:23])[C:17]([NH:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][C:3]=1[OH:12])=[O:18]

Komponenten

4

Edukt 2

HCID 76403Benzoyl chloride, 3,4-dichloro-HCID 38948482-Amino-4-chloro-5-nitrophenol

Produkt 1

HCID 120977653,4-Dichloro-N-(5-chloro-2-hydroxy-4-nitrophenyl)benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2-Amino-4-chloro-5-nitrophenol (34.0g, 0. 18 mole) was slurried in ethyl acetate (250 ml). 3,4-Dichlorobenzoyl chloride (38.g, 0.18 mole) was added and the reaction mixture refluxed for 2 h. After cooling, the beige precipitate was filtered then slurried in hot ethyl acetate (200 ml). Filtration gave the product as a beige solid, 50.5 g, (77%), mp.263-265° C.

Aufarbeitung

  1. temperaturethe reaction mixture refluxed for 2 h
  2. temperatureAfter cooling
  3. filtrationthe beige precipitate was filtered
  4. filtrationFiltration

Quellen und Nachweise

ORD-Eintrag
ord-53573661ffd74ff59cf7b4f1cbe81119
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US06004738

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