Hydrochloric Acid → Ethyl 4-hydroxyphenylglycine, hydrochloride

HRID 613364Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 613364
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1.[ClH:13].[CH3:14][CH2:15]O>>[ClH:13].[CH2:14]([N:8]([C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=1)[CH2:9][C:10]([OH:12])=[O:11])[CH3:15]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 67149N-(4-Hydroxyphenyl)glycine

Produkt 1

HCID 131720465Ethyl 4-hydroxyphenylglycine, hydrochlorideAusbeute 70 %

Versuchsvorschrift

To a suspension of 4-hydroxyphenylglycine (18.00 g, 0.11 mol) in EtOH (100 mL) was added 20% ethanolic HCl (30 mL). The mixture was heated at reflux for 14 h, then was allowed to cool and was concentrated under reduced pressure. The residue was partitioned between saturated aqueous NaHCO3 and EtOAc, and the organic extract was concentrated in vacuo to afford the title compound (15.00 g, 70%).

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 14 h
  3. temperatureto cool
  4. concentrationwas concentrated under reduced pressure
  5. customThe residue was partitioned between saturated aqueous NaHCO3 and EtOAc
  6. extractionthe organic extract
  7. concentrationwas concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-83169680b8704fdea48d4c3c0732106c
Quelldatensatz
uspto-grants-1999_12
Patentnummer
US06008235

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