Phosphorus oxychloride → 2-Chloro-5-phenyloxazole

HRID 613984Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 613984
[C:1]1([C:7]2[O:11][C:10](=S)[NH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Cl)(Cl)([Cl:15])=O>C(N(CC)CC)C>[Cl:15][C:10]1[O:11][C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:8][N:9]=1

Komponenten

4

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 122308765-Phenyl-1,3-oxazole-2-thiol

Produkt 1

HCID 109976262-Chloro-5-phenyloxazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

5-Phenyl-2(3H)-oxazolethione (Acta. Chem. Scand. 23 2879 (1969)) (19.6 g, 0.11 m) and phosphorous oxychloride (70 ml) were stirred with cooling during the cautious addition of triethylamine (12.4 g, 0.123 m). The mixture was then heated under reflux for 20 hours, excess reagents removed under reduced pressure and the residue distilled in vacuo to give the title product as a colourless oil which solidified on standing, b.p. 96°-8° C/0.6 mm, m.p. 34° C.

Aufarbeitung

  1. temperatureThe mixture was then heated
  2. temperatureunder reflux for 20 hours
  3. customexcess reagents removed under reduced pressure
  4. distillationthe residue distilled in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ff4aa09c23e1459388d2253bd77629ad
Quelldatensatz
uspto-grants-1979_03
Patentnummer
US04143047

Notizen zur Reaktion

Wird geladen…