Formaldehyde → 2-Cyano-2-(2,4-dichlorophenyl)hexan-1-ol

HRID 614069

Reaktionsgleichung

Reaktionsgleichung von HRID 614069
[CH2:1]([CH:5]([C:14]#[N:15])[C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=1[Cl:13])[CH2:2][CH2:3][CH3:4].[CH2:16]=[O:17].[OH-].C([N+](CC)(CC)CC)C1C=CC=CC=1>N1C=CC=CC=1>[C:14]([C:5]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=1[Cl:13])([CH2:1][CH2:2][CH2:3][CH3:4])[CH2:16][OH:17])#[N:15]

Komponenten

5

Edukt 3

HCID 712FormaldehydeHCID 74601Benzyltriethylammonium hydroxideHCID 123432572-(2,4-Dichlorophenyl)hexane nitrile

Produkt 1

HCID 233399042-Cyano-2-(2,4-dichlorophenyl)hexan-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To an ice cold stirred solution of α-n-butyl-2,4-dichlorobenzylcyanide (5g., 0.02 mole) in 20 ml. of pyridine containing a suspension of paraformaldehyde (2.4g., 0.08 mole) is added 1 ml. of benzyl triethylammonium hydroxide. The mixture is stirred under nitrogen at room temperature for 16 hours. The reaction mixture is poured into 300 ml. of water and extracted with ether. The combined ether extracts are washed with water, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 5.6g. of a thick oil, which is identified by nmr.

Aufarbeitung

  1. additionis added 1 ml
  2. additionThe reaction mixture is poured into 300 ml
  3. extractionof water and extracted with ether
  4. washThe combined ether extracts are washed with water, saturated sodium chloride solution
  5. dry with materialdried over magnesium sulfate
  6. customThe solvent is evaporated
  7. customto give 5.6g

Quellen und Nachweise

ORD-Eintrag
ord-312fc36fd690474e82e603111cb5a6d3
Quelldatensatz
uspto-grants-1979_03
Patentnummer
US04143137

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