Ammonia → N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyrimidinyl)urea

HRID 614321Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 614321
[NH3:1].Cl.[CH:3]([N:6]([CH:27]([CH3:29])[CH3:28])[CH2:7][CH2:8][N:9]([C:19]1[N:24]=[C:23]([CH3:25])[CH:22]=[C:21]([CH3:26])[N:20]=1)[C:10](=O)[O:11]C1C=CC=CC=1)([CH3:5])[CH3:4]>O1CCCC1>[CH:3]([N:6]([CH:27]([CH3:29])[CH3:28])[CH2:7][CH2:8][N:9]([C:19]1[N:24]=[C:23]([CH3:25])[CH:22]=[C:21]([CH3:26])[N:20]=1)[C:10]([NH2:1])=[O:11])([CH3:5])[CH3:4]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 21329151phenyl N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyrimidinyl)carbamate hydrochloride

Produkt 1

HCID 23349873N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyrimidinyl)urea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Concentrated ammonia (10 ml) is added to a solution of phenyl N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyrimidinyl)carbamate hydrochloride (7.33 g., 0.018 mole) in 50 ml of tetrahydrofuran and the mixture is allowed to stand for twenty-four hours. It is concentrated, water and chloroform are added to the residue, the chloroform is separated and concentrated. Crystallization of the residue from hexane yields N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyrimidinyl)urea melting at 134°-136° C.

Aufarbeitung

  1. waitto stand for twenty-four hours
  2. concentrationIt is concentrated
  3. additionwater and chloroform are added to the residue
  4. customthe chloroform is separated
  5. concentrationconcentrated
  6. customCrystallization of the residue from hexane

Quellen und Nachweise

ORD-Eintrag
ord-b8c3ecceeea549b7bea655d628c4b316
Quelldatensatz
uspto-grants-1979_03
Patentnummer
US04144338

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