2-(cis-2,6-Dimethyl-1-piperidinyl)ethanamine → cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-5,5-dimethyl-2-oxo-1-pyrrolidineacetamide
Reaktionsgleichung
[CH3:1][C:2]1([CH3:14])[CH2:6][CH2:5][C:4](=[O:7])[N:3]1[CH2:8][C:9]([O:11]CC)=O.[CH3:15][C@H:16]1[CH2:21][CH2:20][CH2:19][C@@H:18]([CH3:22])[N:17]1[CH2:23][CH2:24][NH2:25]>>[CH3:15][C@H:16]1[CH2:21][CH2:20][CH2:19][C@@H:18]([CH3:22])[N:17]1[CH2:23][CH2:24][NH:25][C:9](=[O:11])[CH2:8][N:3]1[C:2]([CH3:1])([CH3:14])[CH2:6][CH2:5][C:4]1=[O:7]Komponenten
3
Versuchsvorschrift
From 10 g. of ethyl 2,2-dimethyl-5-oxo-1-pyrrolidineacetate and 11 g. of cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine, following the procedure of Example 9, there is obtained cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-5,5-dimethyl-2-oxo-1-pyrrolidineacetamide as the hemihydrate; m.p. 94°-94.5° C. after recrystallization from isooctane.
Quellen und Nachweise
- ORD-Eintrag
- ord-598508840ffa4da0adac05ffe4e0cd5b
- Quelldatensatz