2-(cis-2,6-Dimethyl-1-piperidinyl)ethanamine → cis-(+/-)-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-alpha-methyl-2-oxo-1-pyrrolidineacetamide

HRID 614484

Reaktionsgleichung

Reaktionsgleichung von HRID 614484
[CH3:1][CH:2]([N:8]1[CH2:12][CH2:11][CH2:10][C:9]1=[O:13])[C:3]([O:5]CC)=O.[CH3:14][C@H:15]1[CH2:20][CH2:19][CH2:18][C@@H:17]([CH3:21])[N:16]1[CH2:22][CH2:23][NH2:24]>>[CH3:14][C@H:15]1[CH2:20][CH2:19][CH2:18][C@@H:17]([CH3:21])[N:16]1[CH2:22][CH2:23][NH:24][C:3](=[O:5])[CH:2]([CH3:1])[N:8]1[CH2:12][CH2:11][CH2:10][C:9]1=[O:13]

Komponenten

3

Edukt 2

HCID 7837022-(cis-2,6-Dimethyl-1-piperidinyl)ethanamineHCID 15044021Ethyl alpha-methyl-2-oxo-1-pyrrolidineacetate

Produkt 1

HCID 22807214cis-(+/-)-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-alpha-methyl-2-oxo-1-pyrrolidineacetamide

Versuchsvorschrift

A mixture of 9.25 g. of ethyl α-methyl-2-oxo-1-pyrrolidineacetate (British Pat. No. 1,309,692) and 11.2 g. of cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine is heated under nitrogen and an air condenser plugged with cotton for 20 hours at 150° C. The excess cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine is evaporated at reduced pressure and the residue is fractionated. The product, cis-(±)-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-α-methyl-2-oxo-1-pyrrolidineacetamide, is obtained as an oil, b.p. 168°-170° C./0.1 mm.

Aufarbeitung

  1. additionA mixture of 9.25 g
  2. customThe excess cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine is evaporated at reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e6aa23c201984e81bea970499bc5dd6f
Quelldatensatz
uspto-grants-1979_03
Patentnummer
US04145347

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