2-(cis-2,6-Dimethyl-1-piperidinyl)ethanamine → cis-(+/-)-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-alpha-methyl-2-oxo-1-pyrrolidineacetamide
Reaktionsgleichung
[CH3:1][CH:2]([N:8]1[CH2:12][CH2:11][CH2:10][C:9]1=[O:13])[C:3]([O:5]CC)=O.[CH3:14][C@H:15]1[CH2:20][CH2:19][CH2:18][C@@H:17]([CH3:21])[N:16]1[CH2:22][CH2:23][NH2:24]>>[CH3:14][C@H:15]1[CH2:20][CH2:19][CH2:18][C@@H:17]([CH3:21])[N:16]1[CH2:22][CH2:23][NH:24][C:3](=[O:5])[CH:2]([CH3:1])[N:8]1[CH2:12][CH2:11][CH2:10][C:9]1=[O:13]Komponenten
3
Versuchsvorschrift
A mixture of 9.25 g. of ethyl α-methyl-2-oxo-1-pyrrolidineacetate (British Pat. No. 1,309,692) and 11.2 g. of cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine is heated under nitrogen and an air condenser plugged with cotton for 20 hours at 150° C. The excess cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine is evaporated at reduced pressure and the residue is fractionated. The product, cis-(±)-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-α-methyl-2-oxo-1-pyrrolidineacetamide, is obtained as an oil, b.p. 168°-170° C./0.1 mm.