Ethyl formate → HCID 178486553, Verbindung

HRID 614532

Reaktionsgleichung

Reaktionsgleichung von HRID 614532
[Na].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[NH:9][C:8](=[O:15])[CH2:7]2.[CH:16](OCC)=[O:17]>C(O)C>[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[NH:9][C:8](=[O:15])[C:7]2=[CH:16][OH:17]

Komponenten

5

Edukt 3

HCID 8025Ethyl formateHCID 2229935,6-Dimethoxyindolin-2-oneHCID 5360545Sodium

Produkt 1

HCID 178486553HCID 178486553, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a warm solution of 1.5 g. sodium in 35 ml. ethanol was added 10 g. of 5,6-dimethoxy oxindole [J. Am. Chem. Soc. 77 3844 (1955)]. Then 30 ml. ethyl formate was added. A solid formed. The mixture was stirred and heated 10 minutes. A stream of nitrogen was blown over the mixture to evaporate as much solvent as possible. Then a solution of 6.5 ml. concentrated hydrochloric acid and 50 ml. water was added. The resulting clear solution was concentrated in vacuum and the resulting solid filtered and washed with ice water. Yield: 10.55 g., m.p. 216°-217° C.

Aufarbeitung

  1. customA solid formed
  2. temperatureheated 10 minutes
  3. customto evaporate as much solvent as possible
  4. additionwater was added
  5. concentrationThe resulting clear solution was concentrated in vacuum
  6. filtrationthe resulting solid filtered
  7. washwashed with ice water

Quellen und Nachweise

ORD-Eintrag
ord-b456b22cbfde4bfebcfc80a07b5d60db
Quelldatensatz
uspto-grants-1979_03
Patentnummer
US04145422

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