HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → 2-[2-(5-Methyl-4-imidazolylmethylthio)-ethylamino]-5-(2-phenylethyl)-4-pyrimidone dihydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | 2(1H)-Pyrimidinone | HCID 68401 | — |
| Edukt | 4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole | HCID 665568 | — |
| Edukt | 5-(2-Phenylethyl)-2-thiouracil | HCID 12945971 | — |
| Edukt | 5-Phenylethyl-2-methylthio-4-pyrimidone | HCID 12951508 | — |
| Produkt | 2-[2-(5-Methyl-4-imidazolylmethylthio)-ethylamino]-5-(2-phenylethyl)-4-pyrimidone dihydrochloride | HCID 23346171 | — |
Reaktionsschritte
5-(2-Phenylethyl)-2-thiouracil (1.8 g) was converted into 5-phenylethyl-2-methylthio-4-pyrimidone (m.p. 160°-161° ex ethanol) by the method described in Example 1(i). Reaction of this pyrimidone (1.55g) with 2-(5-methyl-4-imidazolylmethylthio)-ethylamine (1.1 g) by the method described in Example 1(ii) gave an oil which was dissolved in 2N hydrochloric acid, the solution evaporated to dryness and the residue recrystallised from methanol to give 2-[2-(5-methyl-4-imidazolylmethylthio)-ethylamino]-5-(2-phenylethyl)-4-pyrimidone dihydrochloride, m.p. 214°-218°.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04145546 |
| Quelldatensatz | uspto-grants-1979_03 |
| ORD ID | ord-af83002c64c44d3c8e68996d9b692e00 |
| Quellennotiz | uspto-grants-1979_03 |