Ethyl 3-oxo-2-(2-phenylethyl)butanoate → 5-(2-Phenylethyl)-6-methyl-2-thiouracil

HRID 614682

Reaktionsgleichung

Reaktionsgleichung von HRID 614682
[C:1]1([CH2:7][CH2:8][CH:9]([C:15]([CH3:17])=O)[C:10](OCC)=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:18][C:19]([NH2:21])=[S:20].[O-]CC.[Na+].[Na]>C(O)C>[C:1]1([CH2:7][CH2:8][C:9]2[C:10](=[O:11])[NH:18][C:19](=[S:20])[NH:21][C:15]=2[CH3:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

6

Edukt 4

HCID 219459Ethyl 3-oxo-2-(2-phenylethyl)butanoateHCID 2723790ThioureaHCID 2723922Sodium ethoxideHCID 5360545Sodium

Produkt 1

HCID 129459705-(2-Phenylethyl)-6-methyl-2-thiouracil

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Ethyl α-(phenylethyl)acetoacetate (23.4g) and thiourea (10.65g) were added to a solution of sodium ethoxide in ethanol (100 ml) prepared from sodium (4.6g). The mixture was refluxed for 51/2 hours and evaporated to dryness. The solid residue was dissolved in water and acetic acid was added to pH 4. The white precipitate was filtered off and recrystallised from ethanol to give 5-(2-phenylethyl)-6-methyl-2-thiouracil m.p. 210°-214°.

Aufarbeitung

  1. temperatureThe mixture was refluxed for 51/2 hours
  2. customevaporated to dryness
  3. dissolutionThe solid residue was dissolved in water
  4. additionacetic acid was added to pH 4
  5. filtrationThe white precipitate was filtered off
  6. customrecrystallised from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-65364b47c40c46e6a9ff5cf7862a9b86
Quelldatensatz
uspto-grants-1979_03
Patentnummer
US04145546

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