1-[2-Acetylthiomethyl-5-(trifluoroacetylamino)pentanoyl]-L-proline → HCID 12769727, Verbindung

HRID 614796

Reaktionsgleichung

Reaktionsgleichung von HRID 614796
C([S:4][CH2:5][CH:6]([CH2:17][CH2:18][CH2:19][NH:20]C(=O)C(F)(F)F)[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=O)C>N>[NH2:20][CH2:19][CH2:18][CH2:17][CH:6]([CH2:5][SH:4])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8]

Komponenten

3

Edukt 1

HCID 540982051-[2-Acetylthiomethyl-5-(trifluoroacetylamino)pentanoyl]-L-proline

Produkt 1

HCID 12769727HCID 12769727, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 222AmmoniaLösungsmittel

Versuchsvorschrift

1-[2-Acetylthiomethyl-5-(trifluoroacetylamino)pentanoyl]-L-proline (1 g.) is dissolved in concentrated ammonia (20 ml.) under a blanket of argon and the solution is kept at room temperature for one hour. The excess ammonia is removed in vacuo and the residue is applied to a column of Dowex 50 in the hydrogen cycle. The column is washed with water and the 1-(5-amino-2-mercaptomethylpentanoyl)-L-proline is eluted with a 2 M buffer of pyridine-acetic acid at pH 6.5. Rf =0.5 [CHCl3, MeOH, 38% AcOH (3:2:1)].

Aufarbeitung

  1. customThe excess ammonia is removed in vacuo
  2. washThe column is washed with water
  3. washthe 1-(5-amino-2-mercaptomethylpentanoyl)-L-proline is eluted with a 2 M buffer of pyridine-acetic acid at pH 6.5

Quellen und Nachweise

ORD-Eintrag
ord-980a5b2de8e14297a65925ffac8bbce8
Quelldatensatz
uspto-grants-1979_03
Patentnummer
US04146611

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