1-(3'-Nitro-phenyl)-2-formylamino-propane → 1-(3'-Aminophenyl)-2-formylamino-propane

HRID 614878Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 614878
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][CH:11]([NH:13][CH:14]=[O:15])[CH3:12])[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][CH:11]([NH:13][CH:14]=[O:15])[CH3:12])[CH:7]=[CH:8][CH:9]=1

Komponenten

4

Edukt 1

HCID 213274321-(3'-Nitro-phenyl)-2-formylamino-propane

Produkt 1

HCID 213274251-(3'-Aminophenyl)-2-formylamino-propane

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

5.2 gm of 1-(3'-nitro-phenyl)-2-formylamino-propane was hydrogenated in methanol in the presence of Raney nickel at atmospheric pressure and room temperature. Thereafeter, the catalyst was filtered off, the solvent was evaporated from the filtrate, and the residue was chromatographed on a silicagel column, using methanol/chloroform (2:8) as the flow agent. The eluate was evaporated, and the residue was recrystallized from ethyl acetate, yielding 1-(3'-amino-phenyl)- 2-formylamino-propane which had a melting point of 107°-108° C.

Aufarbeitung

  1. filtrationThereafeter, the catalyst was filtered off
  2. customthe solvent was evaporated from the filtrate
  3. customthe residue was chromatographed on a silicagel column
  4. customThe eluate was evaporated
  5. customthe residue was recrystallized from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-b6727f8875be4d9f93d65efb51c36fa2
Quelldatensatz
uspto-grants-1979_03
Patentnummer
US04146645

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