5-(2-Methyl-2-nitropropoxy)salicylamide → 5-(2-Amino-2-methylpropoxy)salicylamide

HRID 615230Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 615230
[CH3:1][C:2]([N+:16]([O-])=O)([CH3:15])[CH2:3][O:4][C:5]1[CH:13]=[C:9]([C:10]([NH2:12])=[O:11])[C:8]([OH:14])=[CH:7][CH:6]=1>CO>[NH2:16][C:2]([CH3:15])([CH3:1])[CH2:3][O:4][C:5]1[CH:13]=[C:9]([C:10]([NH2:12])=[O:11])[C:8]([OH:14])=[CH:7][CH:6]=1

Komponenten

3

Edukt 1

HCID 137544245-(2-Methyl-2-nitropropoxy)salicylamide

Produkt 1

HCID 137544255-(2-Amino-2-methylpropoxy)salicylamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

11.5 g of 5-(2-methyl-2-nitropropoxy)salicylamide are hydrogenated in 150 ml of methanol at 40°-50° and 80 bar over 5 g of Raney nickel until hydrogen absorption ceases. By filtration and concentration of the filtrate by evaporation, crude 5-(2-amino-2-methylpropoxy)salicylamide is obtained, which, after standing for a relatively long period, crystallises from isopropanol and melts at 115°-117°.

Aufarbeitung

  1. custom80 bar over 5 g of Raney nickel until hydrogen absorption
  2. filtrationBy filtration and concentration of the filtrate
  3. customby evaporation

Quellen und Nachweise

ORD-Eintrag
ord-8d5264f99cff45a996571bcd7158d587
Quelldatensatz
uspto-grants-1985_02
Patentnummer
US04497813

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