Triethylamine → 2(S)-ethyl 1-[(1-phenyl 3-isoquinolyl) carbonyl]piperidine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Triethylamine	HCID 8471	—
Edukt	Ethyl chloroformate	HCID 10928	—
Edukt	1-Phenylisoquinoline-3-carboxylic acid	HCID 407896	—
Edukt	(S)-2-Ethylpiperidine	HCID 5287472	—
Lösungsmittel	Toluene	HCID 1140	—
Produkt	2(S)-ethyl 1-[(1-phenyl 3-isoquinolyl) carbonyl]piperidine	HCID 24842683	86,8%

Reaktionsschritte

Operations are carried out as for Example 7, starting from 2.5 g of 1-phenyl isoquinoline 3-carboxylic acid, 1.15 g of triethylamine, 1.24 g of ethyl chloroformate and 1.2 g of 2(S)-ethyl piperidine in 100 ml of toluene. After chromatography, 3 g of 2(S)-ethyl 1-[(1-phenyl 3-isoquinolyl) carbonyl]piperidine in the form of oil are obtained. αD23 =-2.4° (2% in ethanol).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US04499094
Quelldatensatz	uspto-grants-1985_02
ORD ID	ord-134466a4684c4fd39a4f95e8705478d4
Quellennotiz	uspto-grants-1985_02