Chloride → HCID 20426906, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9](=[O:24])[N:10]([CH2:22][OH:23])[CH:11]=[C:12]3[C:17]=2[NH:16][C:15]2[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=2[S:13]3)=[CH:4][CH:3]=1.[Cl-]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9](=[O:24])[N:10]([CH2:22][O:23][C:9](=[O:24])[CH2:8][CH:5]([CH3:6])[CH3:4])[CH:11]=[C:12]3[C:17]=2[NH:16][C:15]2[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=2[S:13]3)=[CH:4][CH:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To 2.5 g. of 4-(4-chlorophenyl)-2-(hydroxymethyl)-5H-pyrido[3,4-b][1,4]benzothiazin-3(2H)-one (7.0 mmol.) in 25 ml. of pyridine at 0° C. was added 2.5 ml. of isovalery chloride (20.5 mmol.). After stirring for 35 minutes, the mixture was poured onto ice-water and allowed to stand for 16 hours at room temperature. The crude product which formed as an orange precipitate was collected, washed with water, air-dried, and purified using flash chromotography on silica gel, using a mixture of 5% ethyl acetate: 95% methylene chloride as the eluent. Fractions containing the product were combined and triturated with ether to yield 4-(4-chlorophenyl)-2-[(3-methyl-1-oxobutoxy)methyl]-5H-pyrido-[3,4-b][1,4]benzothiazin-3(2H)-one as a yellow solid (1.1 g; 36% yield) having the structural formula, ##STR16## a melting point in the range of 163°-171° C. and the following elemental analysis: