Ammonia → N,N-Dimethyl-2-(4-methyl-3-phenyl-1H-pyrazol-1-yl)-2-phenylacetamide

HRID 615970Notizen

Reaktionsgleichung

[CH3:1][CH:2]([N:6]1[CH:10]=[C:9]([CH3:11])[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:7]1)[C:3]([OH:5])=O.[CH3:18][NH:19][CH3:20].N>>[CH3:18][N:19]([CH3:20])[C:3](=[O:5])[CH:2]([C:1]1[CH:13]=[CH:12][CH:8]=[CH:9][CH:10]=1)[N:6]1[CH:10]=[C:9]([CH3:11])[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:7]1

Komponenten

Edukt 3

HCID 222Ammonia

HCID 674Dimethylamine

HCID 20370468alpha,4-Dimethyl-3-phenyl-1H-pyrazole-1-acetic acid

Produkt 1

HCID 20370480N,N-Dimethyl-2-(4-methyl-3-phenyl-1H-pyrazol-1-yl)-2-phenylacetamide

Versuchsvorschrift

Following the procedure of Example 68, but substituting 4-methyl-α,3-diphenylpyrazole-1-acetic acid for α,4-dimethyl-3-phenylpyrazole-1-acetic acid and dimethylamine for aqueous ammonia, there was obtained N,N,4-trimethyl-α,3-diphenylpyrazole-1-acetamide having a melting point of 135.5°-138° C.

Quellen und Nachweise

ORD-Eintrag: ord-1b061fee49e441ce8074f3055a569f03
Quelldatensatz: uspto-grants-1978_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04072498

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