Methoxycarbonyl isothiocyanate → 1-(3-Methoxycarbonyl-2-thioureido)-4-methylthiomethylthio-2-nitrobenzene
Reaktionsgleichung
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][S:10][CH3:11])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[CH3:15][O:16][C:17]([N:19]=[C:20]=[S:21])=[O:18]>>[CH3:15][O:16][C:17]([NH:19][C:20](=[S:21])[NH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][S:10][CH3:11])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13])=[O:18]Komponenten
3
Versuchsvorschrift
The 1-amino-4-methylthiomethylthio-2-nitrobenzene prepared according to Example VIII is treated with methoxy carbonyl isothiocyanate according to the first paragraph of Example VI to afford 1-(3-methoxycarbonyl-2-thioureido)-4-methylthiomethylthio-2-nitrobenzene. This latter compound is treated according to the iron reduction technique set forth in the third paragraph of Example XIX to afford 2-amino-1-(3-methoxycarbonyl-2-thioureido)-4-methylthiomethylthiobenzene. This latter compound is treated in accordance with the first paragraph of EXAMPLE XVII to afford 1-(3-methoxycarbonyl-2-thioureido)-4-methylthiomethylthio-2-succinamidobenzene.