4-(4-Phthalimidobutyloxy)pyridine → 4-(4-Phthalimidobutyloxy)pyridine hydrochloride

HRID 6162

Reaktionsgleichung

Reaktionsgleichung von HRID 6162
[C:1]1(=[O:22])[N:5]([CH2:6][CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[C:4](=[O:17])[C:3]2=[CH:18][CH:19]=[CH:20][CH:21]=[C:2]12.[ClH:23].CO>CO>[ClH:23].[C:4]1(=[O:17])[N:5]([CH2:6][CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:12]=[CH:13][N:14]=[CH:15][CH:16]=2)[C:1](=[O:22])[C:2]2=[CH:21][CH:20]=[CH:19][CH:18]=[C:3]12

Komponenten

4

Edukt 2

HCID 190791584-(4-Phthalimidobutyloxy)pyridineHCID 21893726Hydrochloride methanol

Produkt 1

HCID 190791574-(4-Phthalimidobutyloxy)pyridine hydrochlorideAusbeute 86,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a suspension of 1.48 g (5.0 mmol) of 4-(4-phthalimidobutyloxy)pyridine in 20 ml of methanol, 15 ml of hydrogen chloride-methanol was added and dissolve. The solvent was distilled off and the residue was crystallized from acetone-ether. The resulting crystals were collected by filtration and washed with ether to give 1.51 g of the desired compound (86.3% yield, colorless crystals), mp. 154°-156° C.

Aufarbeitung

  1. additionwas added
  2. dissolutiondissolve
  3. distillationThe solvent was distilled off
  4. customthe residue was crystallized from acetone-ether
  5. filtrationThe resulting crystals were collected by filtration
  6. washwashed with ether

Quellen und Nachweise

ORD-Eintrag
ord-7872d2ae7d2e4c56a28ce90cf19a337d
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05246948

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