Rmi 14156 → 7alpha-Methyl-estr-5-ene-3beta,17beta-diol
Reaktionsgleichung
[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]2[C@H:8]3[C@H:17]([CH2:18][CH2:19][C@:3]12[CH3:4])[C@@H:16]1[C:11]([CH2:12][C:13](=[O:20])[CH2:14][CH2:15]1)=[CH:10][C@H:9]3[CH3:21].C[C@@H]1C=C2[C@H](CCC(=O)C2)[C@@H]2[C@@H]1[C@H]1[C@@](CC2)(C)C(=O)CC1.C(O)(=O)C.O[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@@H]1C(CC(=O)CC1)=C[C@H]3C>>[CH3:21][C@@H:9]1[CH:10]=[C:11]2[C@H:16]([CH2:15][CH2:14][C@H:13]([OH:20])[CH2:12]2)[C@@H:17]2[C@@H:8]1[C@H:5]1[C@@:3]([CH2:19][CH2:18]2)([CH3:4])[C@@H:2]([OH:1])[CH2:7][CH2:6]1Komponenten
4
Versuchsvorschrift
Following essentially the same procedure but substituting 17β-hydroxy-7α-methyl-estr-5-en-3-one or 7α-methyl-estr-5-en-3,17-dione for the 17β-hydroxy-7α-methyl-estr-5-en-3-one acetate above, also results in the preparation of the desired 7α-methyl-estr-5-ene-3β,17β-diol.